2,031 research outputs found
The Nucleus of Comet 10P/Tempel 2 in 2013 and Consequences Regarding Its Rotational State: Early Science from the Discovery Channel Telescope
We present new lightcurve measurements of Comet 10P/Tempel 2 carried out with
Lowell Observatory's Discovery Channel Telescope in early 2013 when the comet
was at aphelion. These data represent some of the first science obtained with
this new 4.3-m facility. With Tempel 2 having been observed to exhibit a small
but ongoing spin-down in its rotation period for over two decades, our primary
goals at this time were two-fold. First, to determine its current rotation
period and compare it to that measured shortly after its most recent perihelion
passage in 2010, and second, to disentangle the spin-down from synodic effects
due to the solar day and the Earth's orbital motion and to determine the sense
of rotation, i.e. prograde or retrograde. At our midpoint of 2013 Feb 24, the
observed synodic period is 8.948+/-0.001 hr, exactly matching the predicted
prograde rotation solution based on 2010 results, and yields a sidereal period
of the identical value due to the solar and Earth synodic components just
canceling out during the interval of the 2013 observations. The retrograde
solution is ruled out because the associated sidereal periods in 2010 and 2013
are quite different even though we know that extremely little outgassing,
needed to produce torques, occurred in this interval. With a definitive sense
of rotation, the specific amounts of spin-down to the sidereal period could be
assessed. The nominal values imply that the rate of spin-down has decreased
over time, consistent with the secular drop in water production since 1988. Our
data also exhibited an unexpectedly small lightcurve amplitude which appears to
be associated with viewing from a large, negative sub-Earth latitude, and a
lightcurve shape deviating from a simple sinusoid implying a highly irregularly
shaped nucleus.Comment: Accepted by AJ; 12 pages of text (pre-print style), 3 tables, 2
figure
An Analysis of the Factors That Determine When and How to Resolve a Trademark Dispute
Business and war have one thing in common: strategy. âNever to be undertaken thoughtlessly or recklessly, [strategy is] to be preceded by measures designed to make it easy toâ obtain the desired outcome. âA skilled general must be master of the complementary arts of simulation and dissimulation; while creating shapes to confuse and delude the [negotiating adversary] he conceals his true dispositions and ultimate intent.â His actions âare designed to entice the [adversary], to unbalance him, and to create a situation favourable for a decisive counter-stroke.
Book Reviews
Book Reviews of: G. de Bertier de Sauvigny, La France et les français vus par les voyageurs américains, 1814-1948 (Flammarion, 1982-1985) Mary Midgley, Wickedness: A Philosophical Essay (Routledge & Kegan Paul, 1984) Jerome Bruner, Actual Minds, Possible Worlds (Harvard University Press, 1986
A Population-Based Psychometric Validation Study of the Strengths and Difficulties Questionnaire â Hebrew Version
This study presents the psychometric properties of the Strengths and Difficulties Questionnaire â Hebrew version (SDQ-H), used in the Israel Survey on Mental Health among Adolescents (ISMEHA). The SDQ-H was administered to a representative sample of 611 adolescents and their mothers. Structural validity was evaluated by exploratory and confirmatory factor analysis and the Development and Well-Being Assessment (DAWBA) inventory was used as âgold standardâ to test convergent and discriminant validity. Internal consistency and normative scores were established. Agreement was found with the original factor structure, except for the Peer problem scale. Concurrent and discriminant validity varied from fair to very good for most scales. Total Difficulties scores showed better discriminant validity for the adolescentsâ than the mothersâ report for internalizing disorders, and the opposite for externalizing disorders. Internal consistency for the Total Difficulties was 0.77 and for the Hyperactivity scale it was 0.73. It was lower for the other scales, particularly for the Peer problems scale. The findings suggest reasonable psychometric properties of the SDQ-H. Comparisons with other translated SDQ versions are presented
IGR J00234+6141 : a new INTEGRAL source identified as an Intermediate polar
Following an extensive survey of the galactic plane by the INTEGRAL
satellite, new hard X-ray sources are discovered with a significant fraction of
Cataclysmic Variables (CVs) among them. We report here the identification of
one of these hard X-ray sources, IGR J00234+6141, as an accreting magnetic
white dwarf of intermediate polar type. We analyse the high energy emission of
the INTEGRAL source using all available data and provide complementary optical
photometric and spectroscopic data obtained respectively in August and October
2006. Based on a refined INTEGRAL position, we confirm the proposed optical
identification. We clearly detect the presence of a 564 s periodic optical
modulation that we identify as the rotation of the white dwarf. The analysis of
the optical spectrum also demonstrates that the emission lines show a
modulation in radial velocity with an orbital period of Porb = (4.033 +/-
0.005) hr. The two periodicities indicate that IGR00234+6141 is a magnetic CV
of the intermediate polar type. This is one of the faintest and hardest sources
of this type detected by INTEGRAL. This confirms earlier conclusions that IPs
contribute significantly to the population of galactic X-ray sources and
represent a significant fraction of the high energy background.Comment: 6 pages, 7 figures, accepted for publication in A&
Simultaneous Exoplanet Characterization and deep wide-field imaging with a diffractive pupil telescope
High-precision astrometry can identify exoplanets and measure their orbits
and masses, while coronagraphic imaging enables detailed characterization of
their physical properties and atmospheric compositions through spectroscopy. In
a previous paper, we showed that a diffractive pupil telescope (DPT) in space
can enable sub-microarcsecond accuracy astrometric measurements from wide-field
images by creating faint but sharp diffraction spikes around the bright target
star. The DPT allows simultaneous astrometric measurement and coronagraphic
imaging, and we discuss and quantify in this paper the scientific benefits of
this combination for exoplanet science investigations: identification of
exoplanets with increased sensitivity and robustness, and ability to measure
planetary masses to high accuracy. We show how using both measurements to
identify planets and measure their masses offers greater sensitivity and
provides more reliable measurements than possible with separate missions, and
therefore results in a large gain in mission efficiency. The combined
measurements reliably identify potentially habitable planets in multiple
systems with a few observations, while astrometry or imaging alone would
require many measurements over a long time baseline. In addition, the combined
measurement allows direct determination of stellar masses to percent-level
accuracy, using planets as test particles. We also show that the DPT maintains
the full sensitivity of the telescope for deep wide-field imaging, and is
therefore compatible with simultaneous scientific observations unrelated to
exoplanets. We conclude that astrometry, coronagraphy, and deep wide-field
imaging can be performed simultaneously on a single telescope without
significant negative impact on the performance of any of the three techniques.Comment: 15 pages, 6 figures. This second paper, following the paper
describing the diffractive pupil telescope (DPT) astrometric technique, shows
how simultaneous astrometry and coronagraphy observations, enabled by the DPT
concept, constrain the orbital parameters and mass of exoplanet
Deferiprone modulates in vitro responses by peripheral blood T cells from control and relapsing remitting multiple sclerosis subjects
T cells are important mediators of autoimmune inflammation in relapsing remitting multiple sclerosis (RRMS). Previous studies found that deferiprone, an iron chelator, suppressed disease activity in a mouse model of multiple sclerosis, and inhibition of T cell proliferation was implicated as a putative mechanism. The objective of the present study was to examine the effects of deferiprone on suppressing in vitro responses of T cells from control and RRMS subjects. Peripheral blood T cells were co-stimulated with anti-CD3 + anti-CD28 and cultured with or without interleukin 2 (IL-2). Proliferating CD4+ T cells from control and RRMS subjects, cultured with or without IL-2, decreased in response to 75 ÎŒM deferiprone, although the extent of decreased proliferation of CD4+ T cells from RRMS subjects was less than for control subjects. Proliferating CD8+ T cells from control subjects, cultured with or without IL-2, also decreased in response to 75 ÎŒM deferiprone, and this decrease was seen in proliferating CD8+ T cells from RRMS cultured with IL-2. CD4+CD25+ and CD8+CD25+ cells from control subjects, cultured with or without IL-2, declined in 75 M deferiprone, but the decrease was smaller than for the CD4+ and CD8+ proliferative responses. CD4+CD25+ and CD8+CD25+ cells from RRMS subjects showed more variability than for control subjects, but CD4+CD25+ cultured with IL-2 and CD8+CD25+ cells cultured without IL-2 significantly declined in 75 ÎŒM deferiprone. CD4+FoxP3+ and CD4+CD25+FoxP3+ cells tended to remain constant or increase. In summary, deferiprone induced declines in proliferative responses at a dosage that is within peak serum pharmacological concentrations
Monitoring the introduction of pneumococcal conjugate vaccines into West Africa: design and implementation of a population-based surveillance system.
Routine use of pneumococcal conjugate vaccines (PCVs) in developing countries is expected to lead to a significant reduction in childhood deaths. However, PCVs have been associated with replacement disease with non-vaccine serotypes. We established a population-based surveillance system to document the direct and indirect impact of PCVs on the incidence of invasive pneumococcal disease (IPD) and radiological pneumonia in those aged 2 months and older in The Gambia, and to monitor changes in serotype-specific IPD. Here we describe how this surveillance system was set up and is being operated as a partnership between the Medical Research Council Unit and the Gambian Government. This surveillance system is expected to provide crucial information for immunisation policy and serves as a potential model for those introducing routine PCV vaccination in diverse settings
Prognostic value of lymphocyte vascular density and e-cadherin in inflammatory breast cancer
Background: We recently evaluated four laboratory assays, vascular endothelial growth factor D (VEGF-D), E-cadherin, lymphatic vessel density (LVD) measured by podoplanin, and intra-lymphatic tumor emboli (ILTE), which showed notable differences between inflammatory breast cancer (IBC) and non-inflammatory locally advanced breast cancer (LABC). In this study we investigated the potential of the three most quantitatively measured markers, E-cadherin, LVD and VEGF-D, to predict survival in the IBC patients.
Materials and Methods: This study involved the 100 cases identified in the Inflammatory Breast Cancer Registry (IBCR) whose tumors were previously evaluated for the four assays noted above. Living patients were recontacted and survival data were available for up to 17 years. Overall survival (OS) was analyzed through the Kaplan-Meier method stratified by E-cadherin, LVD, VEGF-D, and response to chemotherapy. The differences in OS curves were compared using the log-rank test.
Results: The median OS for patients with high LVD was 6.63 years (95% CI: 4.06 to 10.14), compared to median at 10 years not reached in those with low LVD (p = 0.03). There was a trend towards a longer median OS in patients with high E-cadherin (10.14, 95% CI: 6.63 to 11.67), compared with those with low E-cadherin (6.26, 95% CI: 3.42 to undeterminable). VEGF-D levels showed no correlation with survival.
Conclusion: Low LVD significantly predicts better survival. High E-cadherin expression, as with non-IBC breast cancer and several other malignancies, tends to be associated with a better prognosis
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